Regenerating the liver: not so simple after all? [version 1; referees: 3 approved]
Under normal homeostatic conditions, hepatocyte renewal is a slow process and complete turnover likely takes at least a year.Studies of hepatocyte regeneration after a two-thirds partial hepatectomy (2/3 PH) have strongly suggested that periportal hepatocytes are the driving force behind regenerative re-population, but recent murine studies have br